Welcome to the ISCB Community News Blog

This blog collects news, announcements or other information which could be of interest to our ISCB members. We are a group ISCB members who volunteer to populate this blog on a regular basis. In case you want to become an "ISCB-News Reporter" yourself, let us know: contact ISCB
Don't repost copyrighted content! The guidelines are:
- Include a link to the source page
- Include a short summary about the article. You can quote up to ONE paragraph from the original story, but not more
- Don't repost an entire articles originating from another source
- Never post content without attribution — always include the source

To post a news, please use this form.

Wednesday, June 24, 2015

ISMB/ECCB Social Event--Guiness Storehouse!

Don't miss the ISMB/ECCB 2015 Social Event on Monday, 13 July, at the famous Guinness Storehouse!

Come network, learn about the brewing of Ireland's most famous beer, and enjoy a pint of Guinness.

Tickets are still available online and onsite.
URL: https://www.iscb.org/ismbeccb2015-program/ismbeccb2015-social-events#storehouse

Contact Person: Steven Leard (steven@iscb.org)

Tuesday, June 23, 2015

Announcing the Opening of the DREAM ALS Stratification Prize4Life Challenge

We are pleased to announce that the DREAM ALS Stratification Prize4Life Challenge, the first of the DREAM10 Challenges is now open for participation.

This Challenge focuses on predicting the progression and survival of ALS patients. The Challenge will leverage the PRO-ACT database of more than 8,000 cases as the Challenge training set, and feature several unpublished datasets that will be used for model validation. To learn more and join this Challenge, go to: https://www.synapse.org/#!Synapse:syn2873386/wiki/

Besides joining the ALS Stratification Challenge, we hope you will also pre-register for one or both of the two other DREAM10 Challenges that are currently under preparation. In this way, we can keep you informed about the readiness of these two additional DREAM10 Challenges for participation. Also below, we've also included a current snapshot of the DREAM9.5 Challenges that opened this past winter.

To learn more about DREAM Challenges and Sage Bionetworks please go to: http://dreamchallenges.org/ and http://sagebase.org
URL: http://sagebase.us7.list-manage.com/track/click?u=b146de537186191a9d2110f3a&id=a9f2d91f3f&e=d446602705

Contact Person: Gustavo Stolovitzky (gustavo@us.ibm.com)

Thursday, June 11, 2015

ISCB mourns the loss John Wooley

Dr. John Wooley shaped policy at the U.S. National Science Foundation and U.S. Department of Energy to pave the way for massive growth and transformation in the field of computational biology. He passed away in April after prolonged cancer. After decades spent launching new initiatives in computational biology that pushed forward discoveries, innovation, and national programs in genomics, protein structure, crystallography, and systems biology, Dr. Wooley served as Vice Chancellor for Research and Professor of Pharmacology at the University of California, San Diego.

"John Wooley was an inspiration to me and to our community. His vision saw the potential impact of integrating computer science and biology as we entered the 21st Century. Both fields were transforming as new technologies made possible new types of observations at massive scales. Not only did he shape the direction of the field, but he shaped individuals through his mentorship and unflagging optimism. I had great luck to benefit directly from his guidance and leadership during my early years as a post-doctoral Fellow at the Department of Energy and on through my time as a professor in the Bioinformatics & Systems Biology program at UC San Diego. John will be missed by many," said Terry Gaasterland, Director of the Scripps Genome Center at the Scripps Institution of Oceanography and Professor in the Bioinformatics & Systems Biology program at UC San Diego.

"John gave me my first grant while he was at the NSF. It was the early 90's and the first grant between a biomedical researcher and a computer scientist at Columbia University. What was remarkable was that John gave us more money than we asked for. Many grants later, that has never happened to me again. That was the kind of person John was; breaking rules and tradition to do what he believed in. In that case it was to explore the use of object-oreinted database technologies for answering new types of questions of the rapidly growing corpus of macromolecular structure data. What we learnt from that grant ultimately fed into our work on the RCSB Protein Data Bank (PDB) from which many others were to make landmark discoveries in structural biology and bioinformatics. John saw that coming – that was his strength – seeing the future as if it were today. I was thrilled when John joined us at UCSD and he was instrumental, along with Palmer Taylor, in my securing a tenured professorship in the new School of Pharmacy and Pharmaceutical Sciences even before one brick was laid for the building to house the School. I would periodically visit John in his office and be amazed at his command of what was hot (and what was not) in the ever growing field of computational biology. He kept up this encyclopedic knowledge even as his health fluctuated. Frail on the outside there was enormous strength within; a strength which I and many others gained from. Our young field has lost a pioneer to whom we all owe a great debt," said Philip Bourne, Ph.D., FACMI, Associate Director for Data Science (ADDS) & Founding Editor in Chief of PLOS Computational Biology.
URL: http://www.iscb.org

Contact Person: Nadine Kampman Costello (ncostello@iscb.org)

Wednesday, June 10, 2015

ISCB Seeks Applicatoins for Editors for ISCB Community Journal

ISCB is seeking scholars interested in serving as volunteer editors for the ISCB Community Journal. If you are interested, please submit your nomination using our online system. If you have a colleague who may enjoy serving as a volunteer editor for ISCB, please feel free to forward this information.

The primary responsibility of an editor will be to oversee the content on the ISCB Community Journal homepage. Editors will work with the conferences and have the final decision on the selection of conference editors and editorial board proposed by the conferences. Editors will supervise the conference referee process and ensure the quality standards of referee reports, editorial decision and published papers. Editors will help to promote the journal and to increase the number of conferences publishing in the journal. The ISCB Community Journal editors will work closely with F1000Research to keep improving the journal and make sure it is meeting the aims and objectives of the ISCB. Editors are appointed by the ISCB Board of Directors and will serve a three-year term* with the option to be renewed for one additional term.

Applicants must be a member of ISCB and have significant publishing and reviewing experience, and experience reviewing and working with conference paper and abstract submissions. Due to the high volume of applications, only accepted applicants will be contacted via email.
URL: http://www.iscb.org/call-for-editors

Contact Person: Diane Kovats (dkovats@iscb.org)

Tuesday, June 9, 2015

Let your voice be heard in PLOS user studies

Influence the direction of Open Access science tools by participating in PLOS user studies.

Let your voice be heard

Test drive new concepts and help us refine our designs to make them more accessible for everyone.


Get sneak peeks of our latest tools

We\\\'re constantly building new tools for science publishing, and want to make sure that they are useful and intuitive.


It's easy and fun to participate

We can conduct our short studies in-person at your office or at PLOS headquarters, or remotely using simple user study applications.


Simply take our short survey — we'll keep you in the loop about user study opportunities.

To participate in the survey go to http://us9.campaign-archive2.com/?u=69b1f7f753d370193336032d6&id=a1c361032c&e=07d2cafaa8

URL: http://us9.campaign-archive2.com/?u=69b1f7f753d370193336032d6&id=a1c361032c&e=07d2cafaa8

Contact Person: info@iscb.org (info@iscb.org)

Wednesday, June 3, 2015

BioJS CONFERENCE 3-4 JULY, NORWICH, UK

BioJS CONFERENCE 3-4 JULY, NORWICH, UK
http://conf.biojs.net/

Are you
- a researcher interested in interactive visualization of massive biological datasets on the web?
- a developer interested in data visualization?
- interested to understand current industry-based end user needs?

Would you like to meet recognized leaders in the field of visualization in bioinformatics, including representatives from a variety of SMEs, big pharma and for profit organizations?

It is our pleasure to invite you to join us for the 1st Annual BioJS Conference (BioJS.conf) and hackathon on 3-4 July 2015, hosted at The Genome Analysis Centre (TGAC), Norwich, UK. As part of the conference we will have an industry-led session organized by the Repositive.io SME. The aim of this session is to understand the needs, wants, and limitations of front-end interfaces applied to industry-based end users.

Current confirmed speakers include:

Suzi Lewis (Berkeley)
Benno Schwikowski (Pasteur Institute, Paris)
Henning Hermjakob (EBI)
Ian Mulvany (eLife)
Michiel Helvensteijn (Leiden)
Jessie Kennedy (Napier University, Edinburgh)


Registration open NOW!

Please help us spread the word!

The BioJS.conf Organising Committee

URL: http://conf.biojs.net/

Contact Person: Manuel Corpas (mc@manuelcorpas.com)

Friday, May 22, 2015

CFP: APBC2016 – The Fourteenth Asia Pacific Bioinformatics Conference

*Please distribute it to interested colleagues and students *
=============================================
Full paper submission deadline is due on 30 July, 2015.

APBC2016 - The Fourteenth Asia Pacific Bioinformatics Conference
The Fourteenth Asia Pacific Bioinformatics Conference
San Francisco, United States
11-13 January 2016

http://www.sfasa.org/apbc2016/apbc2016.html

Organization

General Co-Chairs
Jing Huang, Ph.D. (Veracyte, USA)
Ying Lu, Ph.D. (Stanford University, USA)
Philip Bourne, Ph.D. (NIH/OD, USA)

Local Organization Chairs
Jing Huang, Ph.D. (Veracyte, USA)
Hua Tang, Ph.D. (Stanford University)
Haiyan Huang, Ph.D. (University of California, Berkeley, USA)

PC Co-Chairs
Lu Tian, Ph.D. (Stanford University, USA)
Jijun Tang, Ph.D. (University of South Carolina, USA)
Phoebe Chen, Ph.D. (La Trobe University, Australia)
============================================

Important Dates
Full Paper submission: July 30 ,2015
Author notification: August 30 , 2015
Final version due on: October 1 , 2015
Full paper author registration deadline: October 20 ,2015
Conference start and end dates: January 11 - 13 , 2016

The Asia-Pacific Bioinformatics Conference series is an annual forum for exploring research, development and novel applications of Bioinformatics. The past APBC conferences were held in:
· APBC2003 4-7 Feb 2003: Adelaide Australia
· APBC2004 18-22 Jan 2004: Dunedin, New Zealand
· APBC2005 17-21 Jan 2005: Singapore
· APBC2006 13-16 Feb, 2006: Taipei Taiwan
· APBC2007 15-17 Jan, 2007: Hong Kong
· APBC2008 14-17 Jan, 2008: Kyoto Japan
· APBC2009 13-16 Jan, 2009: Beijing China
· APBC2010 18-21 Jan, 2010: Bangalore, India
· APBC2011 11-14 Jan, 2011: Inchon, Korea
· APBC2012 17-19 Jan, 2012: Melbourne, Australia
· APBC2013 21-23 Jan 2013: Vancouver, BC, Canada
· APBC2014 17-19 Jan 2014: Shanghai, China
· APBC2015 21-23 Jan 2015: HsinChu, Taiwan
-----------------------------------------------------------------------

Call for Papers

APBC2016 invites high-quality original full papers on any topic related to Bioinformatics and Computational Biology.

The submitted papers must have not been published or under consideration for publication in any other journal or conference with formal proceedings.
All accepted papers will have to be presented by one of the authors at the conference.

Accepted papers will be invited to be published in the journals BMC Genomics, BMC Bioinformatics, BMC Systems Biology following the journals' publication policy.

Use the following linked site to make your submission
https://easychair.org/conferences/?conf=apbc2016

URL: http://www.sfasa.org/apbc2016/apbc2016.html
Contact Person: Jijun Tang  (jtang@cse.sc.edu)


Friday, May 1, 2015

Call for Editors - ISCB Community Journal

ISCB is seeking scholars interested in serving as volunteer editors for the ISCB Community Journal. If you are interested, please submit your nomination using our online system. If you have a colleague who may enjoy serving as a volunteer editor for ISCB, please feel free to forward this information.

The primary responsibility of an editor will be to oversee the content on the ISCB Community Journal homepage. Editors will work with the conferences and have the final decision on the selection of conference editors and editorial board proposed by the conferences. Editors will supervise the conference referee process and ensure the quality standards of referee reports, editorial decision and published papers. Editors will help to promote the journal and to increase the number of conferences publishing in the journal. The ISCB Community Journal editors will work closely with F1000Research to keep improving the journal and make sure it is meeting the aims and objectives of the ISCB.

Editors are appointed by the ISCB Board of Directors and will serve a three-year term* with the option to be renewed for one additional term.

URL: http://www.iscb.org/call-for-editors

Contact Person: Diane Kovats (dkovats@iscb.org)

Wednesday, April 29, 2015

FASEB PRESIDENT TESTIFIES BEFORE CONGRESS

Bethesda, MD – The President of the Federation of American Societies for Experimental Biology (FASEB), Joseph R. Haywood, PhD, testified before the House Appropriations Subcommittee on Labor, Health and Human Services on April 29. Dr. Haywood advocated for sustained, predictable increases in funding for the National Institutes of Health (NIH).

Dr. Haywood asked the subcommittee to appropriate $32 billion for NIH in fiscal year 2016. He explained that a five year commitment to five percent annual increases would help restore the buying power of the NIH budget, which has declined by more than 22 percent since 2003.

"Every one of us is the spouse, parent, child, dear friend, or acquaintance of someone who is relying on our nation's scientists and physicians to develop tomorrow's treatments," Dr. Haywood told the subcommittee. "[NIH] investment is critical to expedite progress toward the cures that are so desperately needed for all of our loved ones, and for developing innovative technologies and new global industries to sustain the nation's continued economic recovery," he said.

FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
URL: http://www.faseb.org

Contact Person: Debra Speert (dspeert@faseb.org)

Call for Papers: CIBB 2015 special session on 'New knowledge from old data: power of data analysis and integration methods'

September 10-12, 2015
Naples, Italy
http://bioinfo.na.iac.cnr.it/cibb2015/

AIMS AND SCOPE:
Mammalian systems constitute over 200 cell types, each specialized to perform a distinct function, and yet all cell types share the same DNA sequence. Epigenetic marks on DNA and histone tails together with transcription factors are responsible for the interpretation of the DNA sequence in each cellular context to produce a cell type specific transcription signature, and disruptions to these processes lead to disease. Advances in sequencing techniques have accelerated the characterization of epigenetic and transcriptional landscapes across many normal and malignant cell types. The challenge now is to integrate these data to understand transcriptional control at a systems level.

This session will focus on data analysis and data integration methods developed using data from, but not limited to, large consortia projects such as ENCODE, Roadmap Epigenomics or FANTOM to get new biological insights.

SUBMISSIONS:
Conference papers must be prepared following the guidelines illustrated on the CIBB website, which include the requirement of being between 4 and 6 pages in length and having five sections:
1. Scientific background
2. Material and methods
3. Results
4. Conclusion
5. References (no more than 10)

These papers should be submitted in PDF format on the Easy Chair conference system (it is necessary to select this special session in the submission system).
A second submission after the conference, in an extended version, is required to be considered for publication in the Springer\\\'s Lecture Notes in Bioinformatics (LNBI) series ([link]). Moreover, as it has been the case in previous CIBB conferences, we are planning to publish the best papers of CIBB 2015 in an extended form in a special issue of an international scientific journal, including special session papers.

IMPORTANT DATES:
Paper submission deadline: May 30, 2015
Abstract submission deadline: May 30, 2015
Notification of Acceptance: June 19, 2014 Final papers due: July 20, 2015 (*)
Conference: September 10-12, 2015
(*) for the inclusion in the CIBB15 conference proceeding

URL: http://bioinfo.na.iac.cnr.it/cibb2015/

Contact Person: Anagha Joshi (anagha.joshi@roslin.ed.ac.uk)

Tuesday, April 14, 2015

New Master in Bioinformatics at Ghent University

Recent technological advances allow for the generation of huge amounts of molecular data at an ever increasing pace and have dramatically changed our view on life science research. It goes without saying that this data avalanche, together with the need for multi-angle approaches to analyze these data, has created an urgent need for highly trained scientists with an interdisciplinary mindset. The new interfaculty Master of Science in Bioinformatics at Ghent University will start in the academic year 2015-2016 and aims to provide students with the necessary knowledge, skills and attitude to work in such interdisciplinary context.

This Master of Science in Bioinformatics provides a curriculum of 120 ECTS, taught in English. Bioinformatics is inherently multidisciplinary, and requires not only learning skills and knowledge from domains different than those of the bachelor\\\'s degree, but also acquiring a more in-depth knowledge and training in the domain that corresponds to the students' specific background and primary interest. The master is structured to provide both this broadening and deepening.

In a common track (33 ECTS) the master offers courses covering the different application domains of bioinformatics. This track, followed by all students irrespective of their background, primarily aims at educating the interdisciplinary competences that are of key importance to bioinformatics.

Depending on the specific background of the student, this common track is complemented with one of the following specialization tracks (each of which is 87 ECTS):

- Bioscience Engineering (title of 'Bioscience engineer')
- Systems Biology
- Engineering (title of 'Engineer')
URL: http://www.nucleotides2networks.be/master

Contact Person: Dr. Katrijn Vannerum (Katrijn.Vannerum@UGent.be)

Registration Open - Functional Genomics and Systems Biology: From Model Organisms

This long-running Wellcome Trust conference will bring together leading scientists from the fields of genomics, bioinformatics, proteomics and cellular networks to discuss the latest developments and challenges in systems biology.

Advances in DNA sequencing and other high throughput technologies over the past decade have resulted in a wealth of data describing the functions and interactions of various components within the cell. High-resolution maps of genome-wide transcription factors are shedding light on the mechanisms that regulate gene expression. Large-scale interaction networks are improving our understanding of biological systems. To improve our understanding of complex biological systems relevant to health and disease, these data, generated from disparate sources, need to be integrated in a biologically meaningful way.

This conference is an ideal forum to discuss the integration, interpretation and analysis of complex biological data from experimental and computational sources. We welcome the submission of abstracts from all areas relevant to the main themes of the meeting. Several oral presentations will be chosen from the abstracts submitted.


Topics will include
High throughput technologies: applications and analysis
Functional genomics of disease
Model organisms
Single cell analysis
Genome and epigenome regulation
Human genetic variation
Complex networks
Modelling biological networks and pathways


Scientific programme committee
Alvis Brazma EMBL-EBI, UK
Tom Freeman University of Edinburgh, UK
Anne-Claude Gavin EMBL, Germany
Tuuli Lappalainen New York Genome Center, USA
Nicholas Luscombe University College London, UK

Confirmed speakers
Ruedi Aebersold ETH Zurich, Switzerland
Emmanuelle Charpentier Helmholtz Centre for Infection Research, Germany
Peter Fraser Babraham Institute, UK
Marc Friedlander SciLifeLab/Stockholm University, Sweden
Eileen Furlong EMBL, Germany
Roderic Guigo Centre for Genomic Regulation, Spain
Tim Hughes University of Toronto, Canada
Jan Korbel EMBL, Germany
Laura Landweber Princeton University, USA
Ben Lehner Centre for Genomic Regulation, Spain
Leopold Parts Wellcome Trust Sanger Institute, UK
James Sharpe Centre for Genomic Regulation, Spain
Sarah Teichmann EMBL-EBI, UK
Marian Walhout University of Massachusetts Medical School, USA
Michael Yaffe Massachusetts Institute of Technology, USA
Judith Zaugg EMBL, Germany

Dates for your diary:
Abstract & Bursary deadline: 16 September

Registration deadline: 30 September


URL: https://registration.hinxton.wellcome.ac.uk/display_info.asp?id=517

Contact Person: Treasa Creavin (treasa.creavin@hinxton.wellcome.ac.uk)

FASEB Releases New Interactive Map of Federal Science Funding By District

FASEB Releases New Interactive Map of Federal Science Funding By District
Online resource is freely available to the public

Bethesda, MD – The Federation of American Societies for Experimental Biology (FASEB) has released new interactive factsheets summarizing federal science funding in states and U.S. congressional districts. This is the only resource to feature up-to-date information about federal science funding at the district level and make it accessible to the general public.

"This innovative resource illustrates how federal investment in scientific research affects communities in every state," stated Joseph R. Haywood, PhD, FASEB President. "This is an easy way to help our representatives appreciate the impact of federal agency funding on science back home. More importantly, we urge scientists and the public to use this resource to discuss the importance of science funding with their elected officials."

After selecting a state from an online interactive U.S. map, users can drill down to access federal science funding in a single congressional district. Factsheets for each district detail local federal investment by the National Institutes of Health (NIH), National Science Foundation, United States Department of Agriculture, and Department of Energy. In addition to district funding data, users can also access factsheets detailing the impact of NIH investment in each state from the same map.

The district funding information is being shared with more than 100 congressional offices during FASEB's annual Capitol Hill Day today. Fifty representatives of FASEB member societies from 27 states are meeting with House and Senate offices to share FASEB's fiscal year 2016 funding recommendations as well as personal stories of how stable, sustained federal funding for research is essential to improve health and generate new knowledge.

FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
URL: http://www.faseb.org

Contact Person: Lawrence Green (lgreen@faseb.org)

Tuesday, April 7, 2015

Opportunity for early- career bioscientists: Clarkson Early Career Colloquium in Bioscience Crossing Disciplines

Dear Fellow Chairs & Program Heads of Bioscience Departments,

As Chair of Biology at Clarkson University, I am writing to ask for your help at getting out the word and encouraging appropriate applicants for the inaugural Clarkson Early Career Colloquium in Bioscience Crossing Disciplines. This mini-conference is intended for early- career bioscientists, with particular outreach to women and underrepresented minorities seeking academic appointments at small research universities that also have a strong commitment to undergraduate and graduate education. Participants will have an opportunity to network and receive mentoring on how to land a job and what it is like to have a position at an academic institution with high research and teaching expectations such as Clarkson, or at a small research institute such as the Trudeau Institute. It provides an opportunity for Clarkson University and the Trudeau Institute, which intend to be hiring for more positions in the coming years, to meet and make contacts with promising scientists who could enhance and diversify our bioscience faculty. For this first colloquium, we are interested in broad areas of biosciences, including but not limited to bioengineering (including immunoengineering), ecological/evolutionary epidemiology, bioinformatics; behavioral endocrinology, biotechnology, cell biology, and synthetic biology.

I have attached a flyer and detailed announcement of the program. An advertisement will also soon appear in the Chronical of Higher Education.

Please feel free to forward this message to colleagues at your institution or elsewhere who mentor or may know appropriate candidates for this colloquium.


Tom Langen

Chair, Dept. of Biology
Professor, Depts. of Biology, Psychology
Clarkson University
Editorial Board, Environmental Management
mail: (office) Box 5805, Clarkson University, Potsdam NY 13699-5805
mail: (home) 7 Pleasant St., Canton NY 13617
phone:315 268 7933 (office), 315 261 0182 (cell)
URL: http://clarkson.edu/colloquium/

Contact Person: Dr. Tom Langen (tlangen@clarkson.edu)

Monday, April 6, 2015

Quantitative Biology: From Molecules to Man

Quantitative Biology: From Molecules to Man will bring together professionals in science, medicine, and engineering to articulate a vision for the future of improving patient health outcomes. Convergence science provides for a data-driven understanding of intricate biological processes across spatial and temporal scales. Achieving breakthroughs in healthcare requires a specific progression of steps from molecular-level experiments to manipulations and observations in model systems to human-scale investigations, all followed by major epidemiological studies. This one-day meeting will provide a forum for individuals involved in every stage of the process to engage in thought-provoking conversations and to generate actionable ideas for new approaches to finding solutions to some of humanity's most intractable health challenges. For more information please visit the website: www.nyas.org/QuantitativeBiology2015.
Poster Abstract Deadline: May 11, 2015

URL: http://www.nyas.org/QuantitativeBiology2015

Contact Person: Natasha Neysmith (nneysmith@nyas.org)

Thursday, April 2, 2015

IMPACT-F optimizes lead candidates in drug discovery

Pharmaceutical companies use the expert system to forecast drug-uptake in humans.

The artificial intelligence technology, developed by PharmaInformatic, Germany, evaluates if a potential drug will be efficiently taken up in humans. IMPACT-F prioritizes drug-candidates based on predicted drug-uptake ("oral bioavailability"). This ranking allows the most efficient drug-candidates to be chosen for further development.

The technology has been used in therapeutic areas such as cancer, diabetes, inflammation, antivirals and autoimmune diseases. It has been applied to optimize lead candidates and to evaluate oral bioavailability and effective dose prior to human clinical trials. The first drug candidates evaluated with IMPACT-F have now progressed into clinical trials in humans.

Crucially, IMPACT-F improves drug discovery and development at a very early stage, since only the drug structure is needed to reliably forecast oral bioavailability. This enables pharmaceutical companies to focus resources on prospective drug development projects.

Oral bioavailability is one of the most important properties in lead optimisation. A drug must have sufficient oral bioavailability in humans otherwise clinical trials are not effective and drug development is then stopped. Low drug-uptake can result in high inter-individual variability and increases the risk of side-effects and toxicity.


Contact:
Dr. Wolfgang Boomgaarden, phone: +49-4921-993360
PharmaInformatic Boomgaarden, Friesenstr. 36, 26721 Emden, Germany, http://www.pharmainformatic.com
Twitter: https://twitter.com/PharmaInformati

Further detailed information:
http://www.pharmainformatic.com/html/lead_optimization.html#PM

Pharmaceutical companies using IMPACT-F (recent collaborations):
http://www.pharmainformatic.com/html/partnerships.html

URL: http://www.pharmainformatic.com/html/lead_optimization.html

Contact Person: Dr. Wolfgang Boomgaarden (presse@pharmainformatic.com)

Thursday, March 19, 2015

Training Workshops in Bioinformatics and Omics

The Institute for Genome Sciences (IGS) is an internationally known research center located at the University of Maryland School of Medicine in Baltimore. IGS offers five different workshops as part of a professional development program organized by Dr. Michelle Giglio, a faculty member at IGS with over 17 years of experience in genomics and bioinformatics. Dr. Giglio has recruited IGS faculty and staff to form a highly experienced instruction team to provide workshop participants with the knowledge and skills needed to engage in numerous omics applications. All IGS workshops are hands-on, providing attendees with real-world challenges and experience.

Please see our workshop dates listed below.

IMPORTANT DATES:

Metagenome Analysis
October 13th – 16th, 2015

Transcriptome Analysis
May 18th – 20th, 2015

Prokaryotic Comparative Genomics
September 29th – October 1st, 2015

Introduction to Genomics and Bioinformatics
November 2nd – 6th, 2015

FOR MORE INFORMATION & REGISTRATION:
www.igs.umaryland.edu/workshops

EMAIL:
Renée Nathaniel
Workshop Administrative Coordinator
rnathaniel@som.umaryland.edu

URL: http://www.igs.umaryland.edu/education/workshops.php

Contact Person: Renee Nathaniel (rnathaniel@som.umaryland.edu)

Tuesday, March 17, 2015

NIGMS Strategic Plan Now Available

The new NIGMS strategic plan is now available at: http://publications.nigms.nih.gov/strategicplan. We would like to thank all of you who provided input to help shape this document, which outlines many of the priorities and activities that we will pursue over the next 5 years. The plan is designed to serve as a framework to both codify and focus our efforts, while still allowing us the flexibility to pursue untapped opportunities in mission-relevant areas.

In addition to its specific goals, objectives, and implementation strategies, the plan reiterates our commitment to the stewardship of taxpayer funds and an atmosphere of open dialogue, collaboration and shared responsibility with the scientific community. We welcome any suggestions you may have that would help us become as efficient and effective as possible in the pursuit of our mission.
URL: http://publications.nigms.nih.gov/strategicplan/NIGMS-strategic-plan.pdf

Contact Person: Richard Aragon, Ph.D. (richard.aragon@nih.gov)

Wednesday, March 11, 2015

CFP: Workshop on Evolutionary Computation in Computational Structural Biology at ACM GECCO 2015

The focus of this workshop is the use of nature-inspired approaches to central problems in computational structural biology, including optimization methods under the umbrella of evolutionary computation. A particular emphasis will be on progress in the application of evolutionary computation to problems related to any aspects of protein structure modeling, characterization, and analysis.

The workshop will allow for a broader focus on all structure-related problems that necessitate the design of novel evolutionary computation approaches. These may include broader structure modeling settings beyond de novo structure prediction, such as mapping of protein and peptide energy landscapes, structure analysis, design, docking, and other emerging problems in computational structural biology.

We invite submissions on presentations of the
following topics:

Use of artificial life models like cellular automata or Lindenmayer systems in the modeling of biological problems.

Study and analysis of properties of biological systems like self-organization, emergent behavior or morphogenesis.

Multi-objective approaches in the modeling of computational biology problems.

Use of natural and evolutionary computation algorithms in protein structure classification and prediction (secondary and tertiary).

Mapping of protein and peptide energy landscapes.

Modeling of temporal folding of proteins.

Protein design

Protein-ligand and protein-protein docking.

For more information, visit: http://eccsb2015.irlab.org/
URL: http://eccsb2015.irlab.org/

Contact Person: Amarda Shehu (amarda@gmu.edu)

Tuesday, March 10, 2015

Nominations for the National Medals of Science and National Medals of Technology and Innovation

Nominations are currently being accepted for the National Medal of Science and National Medal of Technology and Innovation. The National Medals offer a unique opportunity to showcase the best and brightest minds within your organizations and the outstanding scientists and innovators you work with each and every day.

to submit a nomination for the National Medal of Science, go to: https://www.fastlane.nsf.gov/honawards/medalHome.do;jsessionid=3252526f6b085051de1479869ce2:Dqk3
to submit a nomination for the National Medal of Science.

To download the nomination form for the National Medal of Technology and Innovation, go to: http://www.uspto.gov/learning-and-resources/ip-programs-and-awards/national-medal-technology-and-innovation-nmti

URL: http://www.nsf.gov/od/nms/nominations.jsp

Contact Person: Fae M. Jencks (Fae_M_Jencks@ostp.eop.gov)

Monday, March 9, 2015

PLOS Computational Biology 2014 Reviewer Thank You

The Public Library of Science (PLOS) and the PLOS Computational Biology editorial team would like to express our tremendous gratitude to all those individuals who participated in the peer review process this past year at PLOS Computational Biology. As a journal that is run by and for the scientific community, we depend upon you, the community, to communicate our best work. 2014 was great year for PLOS Computational Biology; during the year, over 2700 reviewers from around the world helped evaluate over 1000 articles.

The names of our 2014 reviewers are listed in S1 Reviewer List. Thank you to all our reviewers for sharing your expertise with the PLOS Computational Biology authors. Your efforts are an important part of making the journal a highly valued open access resource created by and for the benefit of the scientific community.
URL: http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004184

Contact Person: PLOS Computational Biology (alerts@e.plos.org)

Friday, March 6, 2015

The FAceS Project Survey

As part of the FAceS project (www.faces.wi.tum.de/), the Chair for Strategy and Organization (Prof. Isabell M. Welpe) at the Technische Universität München, Germany, is currently conducting a survey about publication practices and performance measurement in science. To attain representative knowledge about publication practices and performance measurement across different countries and disciplines (e.g., biology), we are particularly interested in your assessment and specifications on this topic. Participation in this survey will take approximately 20 minutes. Participants will be offered the chance to participate in the raffle for an iPad mini. Upon request, we will be happy to send you a summary of the results of the survey.

Survey URL: http://ww3.unipark.de/uc/OA/

Contact Person: Ringelhan, Stefanie (performance-management.lso.wi@tum.de)

Raymond and Beverly Sackler Support New NAS Prize for Convergence Research

WASHINGTON — The National Academy of Sciences announced today the creation of the new Raymond and Beverly Sackler Prize in Convergence Research. A generous gift from Raymond and Beverly Sackler and the Raymond and Beverly Sackler Foundation will endow the prize, to be presented annually beginning this year with an inaugural $400,000 award.

"The prize will recognize significant advances in convergence research -- the integration of two or more of the following disciplines: mathematics, physics, chemistry, biomedicine, biology, astronomy, earth sciences, engineering, and computational science -- for achievements possible only through such integration. This year's prize will be awarded for convergence research that benefits human health. Two-thirds of the prize money will be awarded to the selected researcher(s), and the remaining third will go to support the researcher's work.

"Convergence research is responsible for major breakthroughs that are making real impacts on people's lives such as 3-D printing of human tissue, new biofuels, and more precise drug delivery systems," said Raymond Sackler. "Beverly and I hope that the recognition and prestige bestowed through this prize encourages more researchers to work across disciplines and make exciting new discoveries."

"Convergence science is not only necessary but critical to tackling some of the world's most pressing challenges," said National Academy of Sciences President Ralph J. Cicerone. "This generous gift allows the National Academy of Sciences to highlight and support the revolutionary advances in science that result from interdisciplinary ideas and approaches."

Dr. Raymond Sackler is a founder and board member of Purdue Pharma L.P., Stamford, Conn., and the Mundipharma Companies of Europe, Asia and Africa. Individually and through their foundations, Dr. Sackler and his wife Beverly have sponsored scientific and biomedical research at a number of major U.S. academic centers, including: Boston University; CalTech (in collaboration with University of California, Los Angeles); Columbia University; Dana Farber Research Institute; Duke University; Institute for Advanced Study (Princeton); Massachusetts Institute of Technology; MD Anderson Cancer Center; Memorial Sloan-Kettering Cancer Center; New York University; Rockefeller University; Tufts University; University of California, Berkeley (in collaboration with University of California, San Francisco); University of Connecticut; University of Toledo College of Medicine; University of Washington, Seattle; Weill Cornell Medical School; Yale University; and the Harvard-Smithsonian Center for Astrophysics. International academic centers include Cambridge University (UK), Institut des Hautes Etudes Scientifiques (France), Tel Aviv University (Israel); University of Leiden (Netherlands); and the University of Toronto (Canada).

The National Academy of Sciences is a private, nonprofit institution that was established under a congressional charter signed by President Abraham Lincoln in 1863. It recognizes achievement in science by election to membership, and -- with the National Academy of Engineering, Institute of Medicine, and National Research Council -- provides science, technology, and health policy advice to the nation.

URL: http://www.national-academies.org/newsroom

Contact Person: Molly Galvin, Senior Media Relations Officer (news@nas.edu)

Wednesday, February 25, 2015

16th International Conference on Density Functional Theory and its Applications

The 16th International Conference on Density Functional Theory and its Applications is going to take place in Debrecen, Hungary, August 31- September 4, 2015. It will be the following in a series of biennial meetings, which have taken place in Paris (1995), Vienna (1997), Rome (1999), Madrid (2001), Brussels (2003), Geneva (2005), Amsterdam (2007), Lyon (2009), Athens (2011) and Durham (2013).

DFT2015 covers a wide range of topics related with density functional theory. It brings together researchers from all around the world working on the development of the theory, extensions to new fields and providing a broad range of fascinating applications including biomolecular modeling, bio­reactions.
URL: http://dft2015.unideb.hu/home

Contact Person: Professor A. Nagy (anagy@phys.unideb.hu)

Tuesday, January 20, 2015

The DREAM9.5 Challenges

We are pleased to announce that the DREAM Olfaction Prediction Challenge, the first of the DREAM9.5 Challenges is now open for participation. This Challenge focuses on predicting behavioral responses to a panel of odors, and features a first-of-its-kind dataset. To learn more and join this Challenge, go to: https://www.synapse.org/#!Synapse:syn2811262.

Besides joining the Olfaction Prediction Challenge, you can also pre-register for one or more of the other 9.5 Challenges in preparation. In this way we can keep you informed about the readiness of these three Challenges for participation.

Best performers from the DREAM9.5 Challenges will be invited to present at the DREAM Conference (Nov 16, 2015, Philadelphia, PA, USA) with travel expenses covered by the DREAM/Sage organizers. DREAM and Sage Bionetworks are also working with high impact journals to ensure that the methodology developed by the Challenges' best performers will be considered for publication under the Challenge-assisted Peer Review format

The DREAM9.5 Challenges

1) DREAM Olfaction Prediction Challenge: OPEN ·
* Challenge Focus: Predict behavioral responses to a panel of odors
* Join the Challenge: https://www.synapse.org/#!Synapse:syn2811262

2) Prostate Cancer DREAM Challenge. Launch Target: Late February, 2015
* Challenge Focus: Predict survival for prostate cancer patients based on patients' clinical variables
* Learn more and pre-register for this Challenge: https://www.synapse.org/#!Synapse:syn2813558

3) ICGC-TCGA DREAM Somatic Mutation Calling Tumor Heterogeneity Challenge (SMC-Het): Launch Target: Early March, 2015
* Challenge Focus: Identify the best subclonal reconstruction algorithms and to identify the conditions that affect their performance.
* Learn more and pre-register for this Challenge: https://www.synapse.org/#!Synapse:syn2813581

4) ICGC-TCGA DREAM Somatic Mutation Calling RNA Challenge (SMC-RNA): Launch Target: TBA
* Challenge Focus: Benchmark approaches for the calling of various types of RNA mutations and splice variants
* Learn more and pre-register for this Challenge: https://www.synapse.org/#!Synapse:syn2813589

To learn more about DREAM and Sage Bionetworks please go to http://dreamchallenges.org/ and http://sagebase.org

URL: http://dreamchallenges.org/

Contact Person: Gustavo Stolovitzky (gustavo@us.ibm.com)

Thursday, January 15, 2015

ISCB Fight against Ebola Award

Speed is of the essence in combating Ebola; thus, computational approaches should form a significant component of Ebola research. As for the development of any modern drug, computational biology is uniquely positioned to contribute through comparative analysis of the genome sequences of Ebola strains as well as 3-D protein modeling. Other computational approaches to Ebola may include large-scale docking studies of Ebola proteins with human proteins and with small-molecule libraries, computational modeling of the spread of the virus, computational mining of the Ebola literature, and creation of a curated Ebola database.

Taken together, such computational efforts could significantly accelerate traditional scientific approaches. In recognition of the need for important and immediate solutions from the field of computational biology against Ebola, the International Society for Computational Biology (ISCB) announces a prize for an important computational advance in fighting the Ebola virus. ISCB will confer the ISCB Fight against Ebola Award, along with a prize of US$2,000, at its July 2016 annual meeting (ISCB Intelligent Systems for Molecular Biology (ISMB) 2016, Orlando, Florida).
URL: http://f1000research.com/articles/4-12/v1

Contact Person: Diane Kovats (dkovats@iscb.org)

Wednesday, January 14, 2015

FASEB Releases Sustaining Discovery in Biological and Medical Science

This week, the Federation of American Societies for Experimental Biology (FASEB) released an analysis of the threats to continued progress in biological and medical science research. Sustaining Discovery in Biological and Medical Science: A Framework for Discussion examines the challenges facing researchers and presents a series of recommendations to alleviate them.

Sustaining Discovery in Biological and Medical Science: A Framework for Discussiondocuments how shortfalls in federal funding and rising regulatory costs have constrained research budgets. At the same time, scientific opportunities have expanded and more individuals are seeking funding. These opposing trends have resulted in an increasingly unstable research enterprise, delaying scientific discovery.

In the newly released statement, FASEB offers three broad categories of recommendations for consideration:

· Increased advocacy for predictable, sustainable growth in research budgets while striving to make optimal use of existing resources
· Re-examination of the way research is funded, making certain that we provide incentives to encourage the best science and reduce the amount of time spent seeking funding, and
· Improved preparation and utilization of the workforce.

To facilitate feedback from the members of FASEB societies and the broader research community, FASEB has created a website for reviewing the document and recording comments.

FASEB is composed of 27 societies with more than 120,000 members, making it the largest coalition of biomedical research associations in the United States. Our mission is to advance health and welfare by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
URL: http://faseb.org

Contact Person: Lawrence Green (lgreen@faseb.org)

Friday, January 9, 2015

Science Insider Story About Sustaining Discovery

An article on the Sustaining Discovery discussion framework was posted this morning: http://news.sciencemag.org/biology/2015/01/largest-u-s-biomedical-research-society-weighs-nih-s-budget-woes

The Sustaining Discovery website is now live at http://www.faseb.org/SustainingDiscovery/Home.aspx
URL: http://www.faseb.org

Contact Person: Howard H. Garrison, Ph.D. (info@faseb.org)

Thursday, January 8, 2015

FASEB Releases Its Newest Publication in the Horizons in Bioscience Series

Bethesda, MD – The Federation of American Societies for Experimental Biology (FASEB) is pleased to announce the release of the latest publication in the Horizons in Bioscienceseries, "Nanomedicine: A Targeted Approach." The article describes the emerging field of nanoparticle targeting.

Nanomedicine is beginning to change the way scientists and physicians diagnose and treat disease. Unlike conventional therapies, these tiny particles – 1,000 times smaller than the diameter of a human hair – can seek out diseased tissue and access hard to reach places in the body. This article will provide readers with an understanding of what nanoparticles are, how they specifically target diseased tissue, and how they can diagnose and treat some of our most devastating diseases.


The Horizons in Bioscience series is a collection of short, illustrated articles published by FASEB that describe scientific discoveries on the brink of clinical application. Printed copies of the articles are available at no cost for educational or advocacy purposes and can be requested by visiting the Breakthroughs in Bioscience website at www.faseb.org/breakthroughs or by contacting FASEB's Office of Public Affairs at 301-634-7650.
URL: http://www.faseb.org/pdfviewer.aspx?loadthis=http%3A%2F%2Fwww.faseb.org%2FPortals%2F2%2FPDFs%2Fopa%2F2015%2Fnanoparticles%2520horizons%2520article.pdf

Contact Person: Lawrence Green (mailto:lgreen@faseb.org)

Monday, January 5, 2015

RECOMB 2015 Call for Posters and Highlights

RECOMB 2015 (http://www.recomb2015.pl ) invites the submission of abstracts of papers that have been published in a journal after October 1, 2013 or papers that are "in press" at the time of submission and are already linked on the journal web site.

"Highlight" papers can be submitted to the main RECOMB conference as well as to the satellite meetings RECOMB-seq and RECOMB-ccb (http://www.recomb2015.pl/satellite-meetings ). The papers will be selected for presentation by taking into consideration the impact of the work on the field, the likelihood that the work will make a good presentation and the relevance to biological and biomedical research in general.

Please visit https://www.easychair.org/conferences/?conf=recomb2015 to submit your abstract. Submissions must contain an abstract (about 200 words, plain justified text in 10pt character size, formatted to fit A4: 21 x 29.7 cm, including title, author(s), affiliation, e-mail, a link to the published journal version, the identity of the presenter (in case of a multi-authored paper), the name of the meeting(s)submitted to in order of preference (i.e., RECOMB, RECOMB-seq, or RECOMB-ccb) followed by the abstract text. Abstracts lacking this information will not be considered. Accepted presenters for the Highlight Track are required to make the presentation themselves, and must register and pay to attend the conference.

Key dates
Submission deadline: January 15, 2015
Acceptance notification: January 31, 2015

Please also be aware that RECOMB 2015 allows presentation of your work in a poster session. The poster abstract submission is handled by tha same website and the submission deadline is February 15th.

More information can be found on the RECOMB 2015 website: http://www.recomb2105.pl

URL: http://www.recomb2015.pl

Contact Person: Bartek Wilczynski (bartek@mimuw.edu.pl)

Monday, December 15, 2014

Dragonflies on the Hunt Display Amazing Choreography

The dragonfly is a swift and efficient hunter. Once it spots its prey, it takes about half a second to swoop beneath an unsuspecting insect and snatch it from the air.

Scientists at the Howard Hughes Medical Institute's Janelia Research Campus have used motion-capture techniques to track the details of that chase, and found that a dragonfly's movement is guided by internal models of its own body and the anticipated movement of its prey. Similar internal models are used to guide behavior in humans. The work is published in Nature.
URL: http://www.hhmi.org/news

Contact Person: HHMI News (webmaster@hhmi.org)

Monday, December 8, 2014

FASEB Announces 2016 Excellence in Science Award Nomination Season

FASEB EXCELLENCE IN SCIENCE AWARD – 2016 Season
~ CALL FOR NOMINATIONS ~

FASEB is seeking nominations for its 2016 Excellence in Science Award that recognizes the significant accomplishments of women scientists. We look forward to another list of nominees that reads like a 'Who's Who' of international science, containing the names of outstanding women in science who have accomplished scientific work of lasting impact and have contributed substantially to training the next generation of scientists.

The Excellence in Science Award recognizes outstanding achievement by women in biological science. All women who are members of one or more of FASEB Member Societies will be eligible for nomination. Nominations recognize a woman whose career achievements have contributed significantly to further our understanding of a particular discipline by excellence in research.

NOMINATION PACKAGES SHOULD ADDRESS THESE CRITERIA.

Nomination Procedures:
Nominators and their candidates must be members of at least one FASEB Member Society but do not have to be members of the same society. Self-nominations will not be accepted. All nominations must be submitted on the FASEB nomination form (available on the FASEB website). Access to the site will be available as of January 1, 2015.

Nominees will be evaluated on the following criteria:
· Scientific achievements including landmark discoveries, high impact publications, and scientific leadership
· Training of students and postdoctoral fellows including impact on careers and teaching efforts
· Contributions to the broader scientific community, such as leadership in professional organizations, university service and leadership, and public outreach

Nomination Procedures:
Nominators and their candidates must be members of at least one FASEB Member Society but do not have to be members of the same society. Self-nominations will not be accepted. All nominations must be submitted on the FASEB nomination form (available on the FASEB website). Access to the site will be available as of January 1, 2015.
Nomination letter, setting forth in detail:

· Contributions to the field that represent the nominee's outstanding achievement in science
· Evidence of leadership
· Evidence of mentorship
· Evidence of national recognition
· Honors and awards
· Synopsis of selected bibliography
Complete curriculum vitae documenting:

All publications
Leadership roles
Mentorship
Teaching
Honors and recognition
Grant awards
Five nominee reprints demonstrating most significant contributions
Three letters of support from the nominee's peers illustrating impact on the field
Three letters of recommendation from trainees illustrating mentorship and impact on careers
URL: http://www.faseb.org/About-FASEB/Awards/Excellence-in-Science-Award.aspx

Contact Person: Linda Stricker (lstricker@faseb.org)

Wednesday, November 26, 2014

Cytoscape Team at RSGw/DREAM

The Cytoscape team was thrilled to be a part of this year's Regulatory and Systems Genomics conference along with DREAM Challenges. Thanks to support from the National Resource for Network Biology (http://nrnb) and Agilent Technologies, we were able to host a number of unique events integrated into the meeting. The week started off with a sold-out Cytoscape workshop for new users, and a parallel workshop for Cytoscape app developers. These workshops included an introduction to network biology approaches, hands-on sessions with the latest Cytoscape 3.2.0 release, and professional app development training. The next day we shared a well-attended Cytoscape poster session with DREAM Challenges, mixing two communities of like-mined researchers. Finally, during the Systems Biology track, we integrated two Cytoscape App Expo sessions. Each session consisted of four 10-minute presentation about new Cytoscape Apps and how to apply them to systems biology research. All in all, a hugel y successful event with lots of great interactions. Thanks again to the RECOMB and ISCB co-organizers!
URL: http://gladstoneinstitutes.org

Contact Person: Alexander Pico, PhD (apico@gladstone.ucsf.edu)

Wednesday, November 19, 2014

A 45,000-Year-Old Leg Bone Reveals The Oldest Human Genome Yet

Researchers have successfully decoded the genes of a 45,000-year-old man from Siberia. The results offer clues about early human life outside of Africa as well as how humans interacted with Neanderthals and other groups around at the time.

The complete set of genes is the oldest genome of its kind, according to Svante Pääbo, a director at the Max Planck Institute for Evolutionary Anthropology in Leipzig. "It's almost twice as old as the next oldest genome that has been sequenced."

The work of Pääbo and his colleagues was published Wednesday in the journal Nature.

The DNA came from a human femur found in 2008 by a collector scouring the Irtysh River in western Siberia. The femur was handed over to a local paleontologist who in turn gave it to Pääbo's team in Leipzig.

When the age of the bone was revealed, the team couldn't believe it. "We were actually so amazed, we actually had it dated even twice, to make sure," Pääbo says.

Pääbo's team specializes in extracting ancient DNA from bones like these. They carefully set to work retrieving genetic material from bone cells in the femur. Because the bone came from a modern human, they had to take precautions to ensure it wasn't contaminated with their own genetic material.

The results provide a window into an unusual period in human existence.

Modern humans evolved in Africa around 200,000 years ago. They left the continent around 100,000 years ago. But researchers now know that other human-like people were already living in Europe and Asia. These included Neanderthals, large, muscular hominins that lived in the caves of Europe.

"What's exciting about this paper is that it's looking at a very ancient modern human who would have lived around the same time as Neanderthals," says Sarah Tishkoff, a geneticist at the University of Pennsylvania who was not involved with the work.

The bone shows that the Siberian man's DNA contained a tiny amount of Neanderthal genes. In other words, he had some Neanderthal ancestors. It's the latest in a series of papers showing that humans and Neanderthals bred.

Modern Asians, Europeans and Native Americans also have Neanderthal genes, but the Neanderthal gene sequences of the Siberian man were longer, indicating that interbreeding had taken place in the relatively recent past, between 50,000 and 60,000 years ago.

"They actually mixed with each other and did have children," Pääbo says.

As intriguing as the bone is, it leaves many questions about what happened next.

We know that humans thrived and that Neanderthals eventually went extinct, but we still don't know why, says Janet Kelso, a computational biologist at the Max Plank Institute in Leipzig, and a co-author on the paper. "The genetics just doesn't tell us anything about that."

Just as big a mystery is what happened to the Siberian man and his descendants.

Previously it was thought ancient humans hadn't lived so far north 45,000 years ago. And venturing into the region may have been a bad move, Pääbo suspects. The Siberian man's genetic code is distant from other groups of humans, suggesting his family may have gone extinct even before Neanderthals died out.
URL: http://www.npr.org/blogs/health/2014/10/22/358047524/a-45-000-year-old-leg-bone-reveals-the-oldest-human-genome-yet

Contact Person: Geoff Brumfiel (GeoffBrumfiel@npr.org)

Tuesday, November 11, 2014

ISCB announces 2015 Journal Subscriptions now available to ISCB Members

ISCB members can now subscribe to the 2015 issues of our Community Journal at discounted prices:

* Bioinformatics; ISCB Members receive a substantial discount, for more information click here
* Briefings in Bioinformatics Online and Print Discounts available to ISCB Members, for more information click here
* Briefings in Functional Genomics & Proteomics Online and Print Discounts available to ISCB Members for more information, click here
* Computers in Biology and Medicine Online and Print Discounts available to ISCB Members, for more information click here
* Computer Methods and Programs in Biomedicine Online and Print Discounts available to ISCB Members, for more information click here
* Human Molecular Genetics Online and Print Discounts available to ISCB Members, for more information click here
* Journal of Biomedical Informatics Online and Print Discounts available to ISCB Members, for more information click here
* Journal of Computational Biology Online Discount is available to ISCB members. for more information click here


Current members just login to your ISCB membership and select "Subscribe to Journals" from the menu on the left. New members can subscribe during their registration process.
URL: http://www.iscb.org

Contact Person: Suzi Smith (admin@iscb.org)

Wednesday, November 5, 2014

SPRINGER PUBLISHES "CANCER BIOINFORMATICS" BY UGA'S YING XU

Athens, GA - The Computational Systems Biology Lab of the University of Georgia's department of biochemistry and molecular biology is pleased to announce the release of "Cancer Bioinformatics" by Springer.  Authors Ying Xu (UGA), Juan Cui (University of Nebraska, Lincoln) and David Puett (UGA, retired) provide a framework for computational researchers studying the basics of cancer through comparative analyses of omic data. The book discusses how key cancer pathways can be analyzed and discovered to derive new insights into the disease and identifies diagnostic and prognostic markers for cancer.
 
Cancer has been typically studied at the cell level or with xenografted animals, outside of the microenvironmental stresses and pressures that shaped the development of the cancer.  This approach assumes that cancer will develop following the known rules of human biology.  Instead the authors leveraged the data from The Cancer Genome Atlas and found that cancer biology is fundamentally different from human biology.  Their book outlines a radically new framework for basic cancer biology, how cancer develops, and the many paths it can take to survive.  The authors also treat cancer as an evolving complex system, explore future case studies, and summarize the essential online data sources.
 
"Cancer Bioinformatics" is designed for practitioners and researchers working in cancer research and bioinformatics. It is also suitable as a secondary textbook for advanced-level students studying computer science, biostatistics or biomedicine.  You can access an online book review copy at no cost by visiting the book's web page at http://www.springer.com/computer/bioinformatics/book/978-1-4939-1380-0 and listen to a short podcast of lead author Ying Xu talking about cancer and hypoxia on WAMC's Academic Minute - http://academicminute.org/2014/10/ying-xu-university-of-georgia-hypoxia/. 
 
The CSBL is a part of UGA's Franklin College of Arts and Science department of biochemistry and molecular biology and is dedicated to developing a new framework studying cancer and in doing so enable other cancer researchers and computational biologists to join in and contribute.

URL: http://csbl.bmb.uga.edu/
Contact Person: Heather Jensen (hjensen@uga.edu)

Tuesday, November 4, 2014

IJCB: Call for papers

International Journal for Computational Biology (IJCB), which provides a rapid forum for the dissemination of original research articles as well as review articles in all areas of Computational Biology and Bioinformatics invites manuscripts. IJCB is a n official journal of Bioclues Organization, which in turn is an associate of ISCB.

International Journal for Computational Biology is published using an open access publication model, meaning that all interested readers are able to freely access the journal online at http://www.ijcb.in/ without the need for a subscription.

We are maintaining a mirror repository at www.bioinformatics.org for round the clock hassle free readership. Further we are in process of getting indexed with most of the world class citation and indexing databases for better impact and visibility of your research work.

The journal has a distinguished editorial board with extensive academic qualifications, ensuring that the journal maintains high scientific standards and has a broad international coverage. A current list of the journal\\\'s editors can be found at journal website.

Paper should be submitted through online manuscript submission system (Details of which has been given on journal website). Once a paper has been accepted for publication, it will undergo language copyediting, typesetting, and reference validation in order to provide the highest publication quality possible.

Please do not hesitate to contact me if you have any questions about the journal.

With kind regards

Editor-In-Chief
International Journal for Computational Biology (ISSN: 2278-8115)
Web: http://www.ijcb.in/
Email: ijcb@bioclues.org
URL: http://www.ijcb.in/

Contact Person: Chief Editor (ijcb@bioclues.org)

Friday, October 31, 2014

Call for Applications: Research Collaboration Workshop for Women in Mathematical Biology

The National Institute for Mathematical and Biological Synthesis (NIMBioS) is now accepting applications for the Research Collaboration Workshop for Women in Mathematical Biology, to be held June 22-25, 2015, at NIMBioS.

Objectives: This collaborative workshop aims to help build a strong collaboration network of women working on problems in mathematical biology, by facilitating the formation of new collaborative research groups and encouraging them to continue to work together after the workshop. Junior women (tenure track faculty, post-docs and advanced graduate students) in biology, mathematics and related fields are encouraged to apply. The format of this workshop is designed to maximize the opportunities to collaborate:

There will be four teams. Each team will be led by two senior women researchers and will work collaboratively on a specific project. Team members will be chosen from applicants and will consist of junior researchers from both mathematics and biology. Team members can express their project preference in their application Each team will work intensely and present their findings at the end of
the workshop.

Each team is expected to continue their research and obtain results for a joint publication.

Projects: Aerodynamics of spider ballooning; sleep, circadian rhythms and pain; blood flow autoregulation in the kidney; and modeling the effects of antimicrobial therapy on gut microbiota and Clostridium difficile

Location: NIMBioS at the University of Tennessee, Knoxville

Co-Organizer: Anita Layton, Mathematics, Duke Univ.

For more information about the workshop and a link to the online application form, go to http://www.nimbios.org/education/WS_wwmb.html

Participation in the workshop is by application only; 3-4 participants will be selected for each team. Successful applicants will be notified within two weeks of the application deadline. If needed, financial support for travel, meals, and lodging is available for workshop attendees.

Application deadline: March 1, 2015

The National Institute for Mathematical and Biological Synthesis (NIMBioS) (http://www.nimbios.org) brings together researchers from around the world to collaborate across disciplinary boundaries to investigate solutions to basic and applied problems in the life sciences. NIMBioS is sponsored by the National Science Foundation, with additional support from The University of Tennessee, Knoxville.
URL: http://www.nimbios.org

Contact Person: Catherine Crawley, Ph.D. (ccrawley@nimbios.org)

Thursday, October 30, 2014

Top 10 papers reading list for 2013-14: call for nominations

Dear Colleagues,

Please help nominate papers in the field of Regulatory and Systems Genomics, that you've recently read and found to be of particular interest. Relevant areas include Motifs, Grammars, Networks, Systems, Variation, Disease, Personal Genomics, GWAS interpretation, Regulatory Evolution, Comparative genomics, Epigenomics, Physical modeling, Dataset Integration, Splicing regulation, transcriptional regulation, and all areas of gene and genome regulation at the systems level.

You can find the nomination form here: http://goo.gl/forms/ENlRYpOVhD

Please nominate papers that appeared between September 1st, 2013 and August 31st, 2014. You can of course nominate a paper from your own group, but we ask that if you are doing so, to also take the time to nominate at least one paper that was not co-authored by you.

The nomination process will close on November 5th.

Our goal is to identify seminal papers that introduced not only new biological insights, but also key computational methodologies for interpreting biological datasets that have had and will continue to have a lasting impact in the field of Regulatory and Systems Genomics. These will be honored at an awards ceremony in the 2014 RECOMB/ISCB Meeting on Regulatory and Systems Genomics in San Diego on November 9-14, 2014. http://www.iscb.org/recomb-regsysgen2014

Thank you for your help and for being part of our community,

Manolis Kellis and Saurabh Sinha
Co-organizers, RegSysGen Top 10 Papers Reading List
ISCB Special Interest Group On Regulatory & Systems Genomics (RegSys SIG)
http://cosi.iscb.org/wiki/RegSIG:Home
URL: http://cosi.iscb.org/wiki/RegSIG:Home

Contact Person: Manolis Kellis (sinhas@illinois.edu)

Tenth Annual Great Lakes Bioinformatics Conference : GLBIO 2015

Tenth Annual Great Lakes Bioinformatics Conference : GLBIO 2015

An official conference of the International Society for Computational Biology. Organized by the Great Lakes Bioinformatics Consortium. Co-hosted by Purdue University and the International Society for Computational Biology

The Great Lakes Bioinformatics Conference:
~ Provides an interdisciplinary forum for the discussion of research findings and methods.
~ Fosters long-term collaborative relationships and networking opportunities within the domain of computational approaches to biology.

GLBIO has established a strong reputation for building relationships among a nationally prominent bioscience research community, showcasing the North American Great Lakes region as a perfect place to conduct computer-aided research.

Every year, GLBIO organizers prepare a full agenda on the latest developments in bioinformatics and biologically relevant applications. From novice to expert, attendees partake in a variety of workshops, tutorials, presentations, posters, networking, and exhibits during the conference. 2015 program outline:

Monday, May 18: Afternoon tutorials and opening keynote

Tuesday, May 19 and Wednesday, May 20 : All day education including keynote speeches by

Bioinformatics community leaders, cutting edge research through poster sessions and tutorials on a variety of hot topics.
GLBIO 2014 was 2.5 days and consisted of the following presentations:
7 keynotes 7 tutorials
12 highlights talks 9 research talks 13 flash talks
102 poster presentations, presented in two sessions
1 educational panel 1 career symposium 1 sponsored tech talk

The most popular topics included scientific talks on the following topics:
• Applying bioinformatics approaches to further develop medical treatments for cancer Ecological bioinformatics
• Gene expression studies
• Genomic analysis and discovery and pathway analysis
• Machine learning
• Protein structures

Check out the latest schedules and updates at www.iscb.org/glbio2015

URL: http://www.iscb.org/glbio2015

Contact Person: Cori Dossett (glbio@conferencesdesigned.com)

Tuesday, October 28, 2014

Special Issue on Advances in Computational Methods for Genetic Diseases : Extended deadline

Due to Publisher policy, the deadline for the submission of papers has been extended. The new Issue schedule is the following:
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IMPORTANT DATES
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Manuscript Due Friday, 21 NOVEMBER 2014
First Round of Reviews, 13 FEBRUARY 2015
Publication Date, 10 APRIL 2015
URL: http://www.hindawi.com/journals/cmmm/osi

Contact Person: Antonino Staiano (antonino.staiano@uniparthenope.it)

Friday, October 24, 2014

Highlighting How Federally Funded Research Improves Health Ensures Continued Support for Science

FASEB Vice President for Science Policy Hud Freeze, PhD, is driven by the search for new treatments for patients with rare genetic diseases. Specific targets are mutations leading to defects called Congenital Disorders of Glycosylation (CDG). Dr. Freeze is equally passionate about the need to explain how finding cures starts with research to understand basic biological processes, much of which is funded by grants from the federal government. To ensure improved health, he and the FASEB leadership urge scientists to explain their work in public forums and to the media. Some examples of Dr. Freeze's efforts in this regard are linked here: 1) a San Diego TV show with a child suffering from a rare genetic disorder (http://link.brightcove.com/services/player/bcpid1649263564001?bckey=AQ~~,AAAAA5PNMME~,K3tOT-PuafsBOFardsNAXlIchcEkjy_p&bctid=3547868835001); and 2) a video from the Global Genes 2014 Rare Patient Advocacy Summit, session 9, from about minute 11 to 18:40 (http://globalgenes.org/2014summitvideos/).


Contact Person: Joseph Carey (jcarey@faseb.org)

NIH Group Analyzes Grant Processes at Other U.S. Agencies and in the United Kingdom

The National Institutes of Health (NIH) Scientific Management and Review Board (SMRB) on October 14 heard descriptions of the grant processes at other U.S. federal research agencies and at two funding organizations based in the United Kingdom.

Charged with providing guidance to the NIH Director on the organization of the NIH and the implementation of its funding portfolio, a SMRB Working Group since May has explored ways to streamline the grant review, award, and management process. Previous sessions featured presenters from NIH's Office of Extramural Research, the Center for Scientific Review, several NIH institutes and centers; and academic researchers with extensive service on peer review panels.

Sonny Ramaswamy, PhD, Director of the National Institute of Food and Agriculture at the U.S. Department of Agriculture (USDA) presented an overview of the grant-making arm of the agency and the average timelines for applications and awards. He said that the agency was struggling to find ways to shorten its process, which takes approximately 25 to 38 weeks on average. Dr. Ramaswamy flagged USDA's reliance on Requests for Applications (RFAs) or "solicited research" as a key difference between the NIH and USDA granting process, which adds approximately 14 to 16 weeks to the timeline to develop and announce the funding opportunity. Another key difference is that most USDA grants provide one year of funding, with some providing two years; NIH grants typically provide three to five years of support.

The National Science Foundation (NSF) grant review and award process, and potential expediting strategies, were discussed by the agency's Joanne Tornow, PhD, Deputy Assistant Director for Social, Behavioral, and Economic Sciences. She stated that 94 percent of NSF's FY 2013 budget went to extramural research. Of the 48,999 proposals received, the agency funded 10,829 new awards. Approximately three-quarters of all proposals are processed within six months of receipt, with potential bottlenecks caused by difficulty identifying reviewers, additional steps in the review process (e.g., site visit, review by the Director's Review Board or by the National Science Board, etc.), missing documentation, the agency processing a large volume of applications, or the uncertain status of the federal budget. Dr. Tornow noted that NSF has several pilot projects underway to test changes to specific aspects of the peer review process. These include virtual review panels and use of shorter preliminary proposals to reduce the number of full applications that need review.

Representatives of the U.K.'s Wellcome Trust and the Medical Research Council also described their grant processes. Both models incorporate face-to-face interviews with applicants in addition to written reviews.

Alyson Fox, PhD, Wellcome's Head of Grants Management, briefly described the application and review process for both its Investigator Awards, which are equivalent to the NIH R01 grant, and Intermediate Fellowships for postdoctoral scholars. Both processes take approximately 18 weeks with external reviewers engaged only after staff determine applications to be "shortlisted" for further review. During questions and answers, it appeared that this process would not be scalable to NIH, since Wellcome reviews only 160 to 180 applications per cycle for the Investigator Awards and 220 to 250 preliminary applications for the Intermediate Fellowship program.

Declan Mulkeen, PhD, Chief Science Officer for the Medical Research Council briefly described the approximately six month review process by which it funds 350 to 400 individual awards per year. Dr. Mulkeen noted that the process had been reduced from nine to 12 months by implementing shorter application forms and eliminating post-review resubmissions.
URL: http://

Contact Person: Yvette Seger (yseger@faseb.org)

News from NIH

The National Institutes of Health (NIH) recently released several notices of interest to the biological and biomedical research community, ranging from clarifying the role of graduate students and postdocs supported by research grants to the suspension of funding for certain types of research.

On October 10, NIH issued a notice that is particularly significant for postdoctoral scholars, the majority of whom are supported by research project grants. It recognizes their positions as both contributing to a research effort and as an opportunity to develop skills critical to becoming independent researchers. The notice reiterates the clarification released by the Council on Financial Assistance Reform (COFAR) and the Office of Management and Budget (OMB) regarding the dual role of graduate students and postdocs supported on federal research grants. The clarification states, "For non-Federal entities that educate and engage students in research, the dual role of students as both trainees and employees contributing to the completion of Federal awards for research must be recognized in the application of these principles."

An NIH Request for Information (RFI), also issued on October 10, seeks public input to inform the development of a program to facilitate the transition of physician-scientists to independent research careers. Proposed options include: modification of existing mentored career development awards, restructuring of institutional training or career development awards to fulfill the specific needs of physician-scientists, and development of a K99/R00 career transition award that better suits the career trajectory of physician-scientists to obtain input on perceived barriers and possible solutions to reinvigorate this dwindling workforce. The document builds upon the findings and recommendations of the Physician-Scientist Workforce Working Group that was presented the Advisory Committee to the Director, NIH, in June. Responses must be submitted via the RFI website and are due by November 3, 2014.

In accordance with an October 17 statement from the White House, NIH announced a funding pause for new "gain-of-function research" involving influenza, MERS, and SARS viruses. The three viruses were selected because of the significant risk they pose to public health. NIH defines gain-of-function research as any modification of a biological agent — like viruses, bacteria, or toxins — that gives it new or enhanced activity. Research affected under this announcement is limited to projects using any of the three viruses that are anticipated to enhance their pathogenicity or transmissibility via the respiratory system in mammals. The funding pause, which is expected to last nine months, will not impede efforts to characterize or test naturally-occurring versions of these viruses. During the pause, the government will carry out a deliberative process to assess the risks and benefits of such studies and will develop a new Federal policy regarding the funding of this research .
URL: http://

Contact Person: Yvette Seger (yseger@faseb.org)

Friday, October 10, 2014

Survey on credible practice of modeling and simulation in healthcare

With this invitation, we are asking you to complete a survey aimed to establish good practice guidelines in order to realize credibility of computational modeling and simulation (M&S) in healthcare. The survey can be found at:

https://stanforduniversity.qualtrics.com/SE/?SID=SV_4MeRluojMgdVR7n

The survey site will be available until February 15, 2015.

We sincerely appreciate your participation in this survey, which should take no longer than 10 minutes. Your participation is voluntary and your responses will be anonymous. You have been identified as a potential stakeholder in the M&S community. Your support will be instrumental in developing broadly applicable best practices in M&S, for their ultimate utilization in healthcare.

This survey is an initiative of the Committee on Credible Practice of Modeling & Simulation in Healthcare, to understand global and multidisciplinary perspectives in best practices to establish credibility of computational medicine. The Committee was formed as part of interactions within the Interagency Modeling and Analysis Group (IMAG) and Multiscale Modeling Consortium, which provide a platform to facilitate discussions between federal agencies in the United States and investigators within the United States and worldwide.

Please feel free to forward this invitation to others that may have an interest in providing their insight. Thank you for your support. If you have any questions, please feel free to contact me by phone, +1 (216) 445 9523, or by e-mail, erdemira@ccf.org.

Regards,

Ahmet

Ahmet Erdemir, PhD on behalf of Committee on Credible Practice of
Modeling & Simulation in Healthcare
http://wiki.simtk.org/cpms

URL:

Contact Person: Joy Ku (joyku@stanford.edu)

Wednesday, October 8, 2014

Call for Papers: Special issue on machine learning techniques in biological data mining

Dear colleague,

We invite you to submit a paper for a supplement to be published in Bioinformatics and Biology Insights in the next twelve months. The journal is extensively indexed and all published papers appear in Pubmed. The supplement focuses on current developments in machine learning techniques in biological data mining. In this supplement, we will discuss the use of machine-learning techniques to extract meaningful information from genetic and clinical data with the primary objective of answering pressing biomedical questions. Topics of interest include but are not limited to:

* Building predictive models for complex phenotypes from large-scale biological data
* Discovering biological networks and pathways underlying biological processes and diseases
* Processing of new/next-generation sequencing (NGS) data for genome structural variation analysis, discovery of biomarkers and mutations, and disease risk assessment
* Discovery of genotype-phenotype associations
* Novel methods and frameworks for mining and integrating big biological data
* Comparative genomics
* Metagenome analysis using sequencing data
* RNA-seq and microarray-based gene expression analysis
* Genome-wide analysis of non-coding RNAs
* Genome-wide regulatory motif discovery
* Correlating NGS with proteomics data analysis
* Functional annotation of genes and proteins
* Chemo-informatics: Drug discovery, Virtual screening and Combinatorial chemistry
* Knowledge discovery in clinical data and electronic medical records

If you are interested in contributing, please contact the guest editors Dr. Gaurav Pandey (gaurav.pandey@mssm.edu) and Dr. Gerard Dumancas (gerard.dumancas@okstate.edu) to discuss your contribution. In order to proceed, please submit a manuscript title and agreed submission date as soon as possible. Submissions must be received for peer review on or before June 1, 2015. We hope to hear from a lot of you!
URL: http://www.la-press.com/journal-bioinformatics-and-biology-insights-j39

Contact Person: Gaurav Pandey (pandey.gaurav@gmail.com)

Friday, October 3, 2014

Submission of manuscripts for publication

Journal of Biological and Food Science Research (JBFSR) with ISSN: 2277-0828 is currently accepting manuscripts for publication. JBFSR is an open access, international, multidisciplinary, blind peer-review journal which publishes high-quality solicited and unsolicited research and review articles in English, in all areas of bioinformatics, biology, microbiology, food science, botany, life science, biochemistry, optometry, zoology, industrial biology, industrial microbiology, clinical microbiology, laboratory science, cell and animal biology, genetics and molecular biology, medical sciences, dentistry, medical diagnosis and laboratory, computational biology, etc.

JBFSR is a rapid response journal that publishes an issue monthly. One of our objectives is to inform contributors (authors) of the decision on their manuscript(s) within a MONTH of submission. Following acceptance, a paper would be published in the next available issue. JBFSR provides immediate open access to published articles without any barrier.

Publishing your article with JBFSR means that the article will be available to millions of researchers in the field of Biological and Food Science Research because our large and diverse readership base comprises of millions of researchers. Majority of the journal's readers are academic lecturers, students, policy makers in the beverage industry, food and canning industry, and policy makers in government. Our journal support free downloading of published articles by scholars for use as materials for lecture, by government officials for policy making, and corporate researchers to favour corporate organizations world-wide. Also, JBFSR is a registered member of several local and international organizations? making it possible for the far and wide distribution of published articles. We ask you to support this initiative by publishing your paper(s) in this journal.

Authors should send their manuscript(s) as MS Word attachment to our editorial office through the following email address:
submit.jbfsr@onlineresearchjournals.org or
jbfsr.onlineresearch@yahoo.com; Instructions for authors and other details are available on our website www.onlineresearchjournals.org/JBFSR.
You may wish to visit
http://onlineresearchjournals.org/JBFSR/archive.htm for articles already published in this journal.
URL: http://www.onlineresearchjournals.org/JBFSR

Contact Person: Chairy Onyia (submit.jbfsr@onlineresearchjournals.org)

Thursday, October 2, 2014

Call for Bioclues Innovation, Research and Development (BIRD) awards for the year 2014

To encourage budding bioinformaticists in India who have had made outstanding contributions in the area of Bioinformatics and Functional Genomics, we have initiated the Bioclues Innovation, Research and Development (BIRD) awards in the year 2011. The call for the 2014 is now open. Do you have the following traits?

●Promoted international standards for R and D in India.

●Created novel models/opportunities or Bioinformatics-based tools.

●Mentored student researchers.

●S/he is less than 35 years and preferably a PhD in Bioinformatics or related field.

●Secured grants in organizing international events and activities in support of Bioinformatics.

●Have penchant for and respect Open Access

More at www.bioclues.org
URL: http://www.bioclues.org

Contact Person: Prashanth Suravajhala (prash@bioclues.org)

Friday, September 26, 2014

Computer method IMPACT-F replaces unreliable animal tests

Experiments in animals are used to estimate drug-uptake in humans. If drug-uptake in animals is too low, drug candidates are excluded from further development.

But large differences exist on drug-uptake between animals and humans. This also applies to very successful commercial drugs, called blockbuster drugs, with annual sales of more than one billion US Dollar.

Drug-uptake studies in animals are misleading: Aripiprazole and Esomeprazole, the most sold drugs of 2013, have low oral bioavailability in animals, but drug-uptake in humans is high.

The new expert system IMPACT-F replaces animal trials on drug-uptake.

Pharmaceutical companies have applied the expert system to evaluate human drug-uptake in various therapeutic areas such as diabetes, inflammation, antivirals, autoimmune diseases and cancer.

The expert system evaluates drug-uptake in humans significantly more reliably than animal trials. This further increases the prospects of human clinical trials, because the optimum oral dose for first-in-human clinical trials can be determined much more accurately.

Efficacy issues are identified as the main reason why clinical trials fail.

About PharmaInformatic:
The biotech company PharmaInformatic was founded in 2004 and provides ADME knowledge bases and predictive tools (expert systems) to improve drug discovery and development. The company is based in Germany.
www.pharmainformatic.com


Further detailed information:
http://www.pharmainformatic.com/html/partnerships.html

http://www.pharmainformatic.com/html/blockbuster_drugs.html

URL: http://www.pharmainformatic.com

Contact Person: Dr. Wolfgang Boomgaarden (presse@pharmainformatic.com)

Friday, September 19, 2014

Extended deadline Special Issue: Advances in Computational Methods for Genetic Diseases

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CFP
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Special Issue - Advances in Computational Methods for Genetic Diseases - Computational and Mathematical Methods in Medicine, Hindawi

Due to potential authors requests, the deadline for the submission of papers has been extended. The new Issue schedule is the following:

_________________
IMPORTANT DATES
_________________

Manuscript Due Friday, 19 OCTOBER 2014
First Round of Reviews Friday, 12 December 2014
Publication Date Friday, 6 February 2015

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CALL FOR PAPERS
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Genetic diseases are widely studied for the relevant impact on the human health. In the last years, a large amount of experimental data has been available. The identification of new strategies for elaborating such experimental data is becoming more and more necessary since the large amount of information can sometimes represent a real obstacle for the effective identification of relevant findings. The aim of the special issue is to review the recent advances about the research on computational methods concerning with genetic diseases. Potential topics include, but are not limited to:

Computational and mathematical methods for the following:
- Evaluating the pathogenicity of novel genetic variants
- The evaluation of protein folding and/or protein-protein interactions in presence of genetic variants
- Analysis of experimental data from next generation sequencing
- Searching for variant/mutation databases for massive data analysis
- Analysis of "omics" data
- Analysis of complex diseases, namely, multifactorial and polygenic, for example, diabetes, hypertension and dyslipidemia
- Variant analysis from Genome Wide Association studies
- Analysis of common genetic variants (i.e., SNPs, HLA genotypes, microsatellites)
- Analysis of quantitative trait loci
- The integration of genetic and non genetic factors for prediction of disease predisposition
- The identification of potential gene regulatory elements (i.e., binding of transcription factors, and miRNAs)
- Analysis of gene expression data
- Analysis of biological models of genetic diseases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/cmmm/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/cmmm/genet/

URL: http://www.hindawi.com/journals/cmmm/si/828505/cfp/

Contact Person: Antonino Staiano (antonino.staiano@uniparthenope.it)
URL: http://www.hindawi.com/journals/cmmm/osi/

Contact Person: Antonino Staiano (antonino.staiano@uniparthenope.it)