Nature Article: Predicting new molecular targets for known drugs

see the News and Views from A.L. Hopkins:

Drug discovery: Predicting promiscuity

"Computational methods that reliably predict the biological activities of compounds have long been sought. The validation of one such method suggests that in silico predictions for drug discovery have come of age....."

and the full article by Michael J. Keiser et.al.: Predicting new molecular targets for known drugs