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Wednesday, December 2, 2009

Forensic Bioinformatics Analyses Lead to Suspension of Clinical Trials

In its December issue the Annals of Applied Statistics feature an article on reproducible research in high-throughput biology by Keith A. Baggerly and Kevin R. Coombes of the M.D. Anderson Cancer Center. In their article they describe how they used "Forensic Bioinformatics" to identify an array of problems - in many cases simple errors - in published studies that are the basis of several ongoing clinical trials. These trials have now been suspended, as the findings by Baggerly and Coombes suggest that patients could be harmed.

Stories published on October 2nd, October 9th and October 23rd in The Cancer Letter contain details about the developments.